Difference between revisions of "IPLab:Lab 3:Healed Myocardial Infarction"
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== Additional Resources == | == Additional Resources == | ||
=== Reference === | === Reference === | ||
− | + | * [http://emedicine.medscape.com/article/155919-overview eMedicine Medical Library: Myocardial Infarction] | |
+ | * [http://www.merckmanuals.com/professional/cardiovascular_disorders/coronary_artery_disease/acute_coronary_syndromes_acs.html Merck Manual: Acute Coronary Syndromes] | ||
=== Journal Articles === | === Journal Articles === |
Revision as of 22:33, 21 August 2013
Contents
Clinical Summary[edit]
This 37-year-old white female with a 22 year history of insulin-dependent diabetes was admitted to the hospital 10 hours prior to death complaining of chest pain and shortness of breath. Three months before, she had begun to experience progressive weakness and for the previous 3 weeks she noticed increasing dyspnea on exertion and worsening of a chronic cough.
Autopsy Findings[edit]
Autopsy showed a 340-gram heart with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowing of all coronary arteries especially the left anterior descending. The lungs showed pulmonary edema and early bronchopneumonia.
Images[edit]
This is a higher-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is at the top (1) and the fibrous connective tissue scar is at the bottom (2). Note the presence of occasional hypereosinophilic myocytes indicating recent acute ischemic injury to this region of old scar tissue (arrows).
This is a low-power photomicrograph of two sections of myocardial tissue stained with a trichrome stain to demonstrate fibrous connective tissue (blue). The section on the left is from a heart with a recent myocardial infarction. Notice the absence of fibrous connective tissue. The section on the right is from a heart with an old healed infarct and it contains extensive fibrous connective tissue scars.
Study Questions[edit]
Additional Resources[edit]
Reference[edit]
Journal Articles[edit]
Images[edit]
Related IPLab Cases[edit]
Shortness of breath is a common clinical manifestation of heart failure.
A normal heart weighs 300 grams (range: 270 to 360 grams).
Atherosclerosis is the deposition of lipid into the intima of arteries, resulting in narrowing of the vessel lumen.
Pulmonary edema refers to the accumulation of fluid in the pulmonary alveolar and tissue spaces as a result of changes in capillary permeability and/or increases in capillary hydrostatic pressure.
Myocardial infarction is necrosis of myocardial tissue which occurs as a result of a deprivation of blood supply, and thus oxygen, to the heart tissue. Blockage of blood supply to the myocardium is caused by occlusion of a coronary artery.
An occlusion is a blockage.
An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.