Cytologically Yours: Unknowns: 201310: Case 4

Clinical History

57 year old female with BOOP as per an open lung biopsy. She has a history of breast carcinoma status post mastectomy. She presented to the emergency room with hemoptysis. The specimen is a bronchial brushing.

Cytology

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Resident Question

• Diagnosis

• Squamous Cell Carcinoma
  • Smokers
  • May be associated with a paraneoplastic syndrome
    • Hypercalcemia due to production of PTHrP
  • ⊕: p63, CK5/6
  • ⊖: TTF-1, neuroendocrine markers, CK7, CK20

Cell Block

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