IPLab:Lab 6:Senile Amyloidosis - Revision history

Peter Anderson: /* Autopsy Findings */

2020-07-09T00:23:29Z

Autopsy Findings

← Older revision		Revision as of 19:23, 8 July 2020
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	At autopsy the heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.		At autopsy the heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.

	~~== Autopsy Findings ==~~
	The heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-07-09T00:23:22Z

Clinical Summary

← Older revision		Revision as of 19:23, 8 July 2020
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	== Clinical Summary ==		== Clinical Summary ==
	This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.		This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.

			At autopsy the heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.

	== Autopsy Findings ==		== Autopsy Findings ==

Seung Park at 16:21, 3 January 2014

2014-01-03T16:21:37Z

← Older revision		Revision as of 11:21, 3 January 2014
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	File:IPLab6SenileAmyloidosis5.jpg\|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.		File:IPLab6SenileAmyloidosis5.jpg\|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab6SenileAmyloidosis</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Images */

2013-08-30T01:37:11Z

Images

← Older revision		Revision as of 20:37, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/65-amyloidosis PEIR Digital Library: Amyloidosis Images]		* [{{SERVER}}/library/index.php?/tags/65-amyloidosis PEIR Digital Library: Amyloidosis Images]
	* [http://library.med.utah.edu/WebPath/CINJHTML/CINJIDX.html#4 WebPath: Cellular Accumulations]		* [http://library.med.utah.edu/WebPath/CINJHTML/CINJIDX.html#4 WebPath: Cellular Accumulations]
	* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html#11 WebPath: Cardiomyopathies]		* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html#11 WebPath: Cardiomyopathies]

Seung Park at 04:13, 23 August 2013

2013-08-23T04:13:57Z

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 * <spoiler text="At what age does senile amyloidosis usually develop?">Eighth and ninth decades.</spoiler>
 * <spoiler text="Where else may senile amyloid deposits occur?">Senile amyloid deposits also occur in the lungs, pancreas, and spleen. Senile cerebral amyloidosis occurs due to deposition of A beta 2 protein in cerebral blood vessels and in senile plaques of Alzheimer's disease patients.</spoiler>
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

Peter Anderson at 15:55, 21 August 2013

2013-08-21T15:55:40Z

← Older revision		Revision as of 10:55, 21 August 2013
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	File:IPLab6SenileAmyloidosis5.jpg\|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.		File:IPLab6SenileAmyloidosis5.jpg\|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.
	</gallery>		</gallery>

			== Study Questions ==
			* <spoiler text="What protein makes-up senile amyloid in the ventricle of the heart?">Transthyretin.</spoiler>
			* <spoiler text="What protein makes-up senile amyloid in the atrium of the heart?">Atrial natriuretic peptide.</spoiler>
			* <spoiler text="At what age does senile amyloidosis usually develop?">Eighth and ninth decades.</spoiler>
			* <spoiler text="Where else may senile amyloid deposits occur?">Senile amyloid deposits also occur in the lungs, pancreas, and spleen. Senile cerebral amyloidosis occurs due to deposition of A beta 2 protein in cerebral blood vessels and in senile plaques of Alzheimer's disease patients.</spoiler>

	{{IPLab 6}}		{{IPLab 6}}

	[[Category: IPLab:Lab 6]]		[[Category: IPLab:Lab 6]]

Seung Park at 14:30, 21 August 2013

2013-08-21T14:30:10Z

← Older revision		Revision as of 09:30, 21 August 2013
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			== Clinical Summary ==
			This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.

			== Autopsy Findings ==
			The heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.

	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">

Seung Park: Created page with "== Images == File:IPLab6SenileAmyloidosis1.jpg|This is a gross photograph of section of heart tissue from this case. The tissue was fi..."

2013-08-20T20:25:07Z

Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab6SenileAmyloidosis1.jpg|This is a gross photograph of section of heart tissue from this case. The tissue was fi..."

New page

== Images ==
<gallery heights="250px" widths="250px">
File:IPLab6SenileAmyloidosis1.jpg|This is a gross photograph of section of heart tissue from this case. The tissue was firm and had a waxy texture. If you use your imagination you can see pale yellow areas within this tissue which represent the amyloid deposits.
File:IPLab6SenileAmyloidosis2.jpg|This is a low power photomicrograph of the heart tissue from this case. At this magnification the structure looks relatively normal.
File:IPLab6SenileAmyloidosis3.jpg|This is a higher-power photomicrograph of the heart tissue from this case. Note the amyloid deposition throughout the myocardium (1) as well as deposition in the wall of the blood vessel (2).
File:IPLab6SenileAmyloidosis4.jpg|This is a higher-power photomicrograph of extracellular amyloid (1) and deposition of amyloid in the vessel wall (2).
File:IPLab6SenileAmyloidosis5.jpg|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.
</gallery>

{{IPLab 6}}

[[Category: IPLab:Lab 6]]