IPLab:Lab 6:Scleroderma - Revision history

Peter Anderson: /* Autopsy Findings */

2020-07-08T23:38:40Z

Autopsy Findings

← Older revision		Revision as of 18:38, 8 July 2020
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	Upon opening the thorax at autopsy there was 600 cc of cloudy serous fluid in each hemithorax and 100 cc of similar fluid in the pericardial sac. The heart weighed 530 grams and there was thickening of both the left and right ventricular walls. The liver weighed 1880 grams and was congested. The spleen weighed 200 grams and was also congested. The combined lung weight was 1875 grams; the lungs were markedly fibrotic with severe emphysema. In addition, dermal thickening was evident throughout the body and the wall of the esophagus was thickened and firm.		Upon opening the thorax at autopsy there was 600 cc of cloudy serous fluid in each hemithorax and 100 cc of similar fluid in the pericardial sac. The heart weighed 530 grams and there was thickening of both the left and right ventricular walls. The liver weighed 1880 grams and was congested. The spleen weighed 200 grams and was also congested. The combined lung weight was 1875 grams; the lungs were markedly fibrotic with severe emphysema. In addition, dermal thickening was evident throughout the body and the wall of the esophagus was thickened and firm.

	~~== Autopsy Findings ==~~
	Upon opening the thorax there was 600 cc of cloudy serous fluid in each hemithorax and 100 cc of similar fluid in the pericardial sac. The heart weighed 530 grams and there was thickening of both the left and right ventricular walls. The liver weighed 1880 grams and was congested. The spleen weighed 200 grams and was also congested. The combined lung weight was 1875 grams; the lungs were markedly fibrotic with severe emphysema. In addition, dermal thickening was evident throughout the body and the wall of the esophagus was thickened and firm.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-07-08T23:38:33Z

Clinical Summary

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	== Clinical Summary ==		== Clinical Summary ==
	This 29-year-old black female had a history of scleroderma involving the lung, kidney, heart, and skin. Her main clinical problems centered on her restrictive lung disease. She was able to live at home with supplemental oxygen but recently she had developed edema, chest pain, weakness, light-headedness, and a loss of appetite. The patient was admitted to the hospital with a working diagnosis of congestive heart failure brought on by her lung disease. Echocardiographic evaluation revealed a pericardial effusion that was tapped. Soon after this procedure her respiratory status degenerated and she required intubation. Despite aggressive supportive treatment for her cardiac and pulmonary problems, she could not be weaned from the ventilator. Two weeks after admission she became febrile and Gram positive cocci were isolated from sputum culture. She was placed on antibiotics but her condition deteriorated and she developed bradycardia followed by electromechanical dissociation (EMD).		This 29-year-old black female had a history of scleroderma involving the lung, kidney, heart, and skin. Her main clinical problems centered on her restrictive lung disease. She was able to live at home with supplemental oxygen but recently she had developed edema, chest pain, weakness, light-headedness, and a loss of appetite. The patient was admitted to the hospital with a working diagnosis of congestive heart failure brought on by her lung disease. Echocardiographic evaluation revealed a pericardial effusion that was tapped. Soon after this procedure her respiratory status degenerated and she required intubation. Despite aggressive supportive treatment for her cardiac and pulmonary problems, she could not be weaned from the ventilator. Two weeks after admission she became febrile and Gram positive cocci were isolated from sputum culture. She was placed on antibiotics but her condition deteriorated and she developed bradycardia followed by electromechanical dissociation (EMD).

			Upon opening the thorax at autopsy there was 600 cc of cloudy serous fluid in each hemithorax and 100 cc of similar fluid in the pericardial sac. The heart weighed 530 grams and there was thickening of both the left and right ventricular walls. The liver weighed 1880 grams and was congested. The spleen weighed 200 grams and was also congested. The combined lung weight was 1875 grams; the lungs were markedly fibrotic with severe emphysema. In addition, dermal thickening was evident throughout the body and the wall of the esophagus was thickened and firm.

	== Autopsy Findings ==		== Autopsy Findings ==

Peter Anderson: /* Virtual Microscopy */

2015-09-16T19:40:28Z

Virtual Microscopy

← Older revision		Revision as of 14:40, 16 September 2015
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	== Virtual Microscopy ==		== Virtual Microscopy ==
	=== Lung ===		=== Lung: Scleroderma ===
	<peir-vm>IPLab6Scleroderma</peir-vm>		<peir-vm>IPLab6Scleroderma</peir-vm>

	=== Skin ===		=== Normal Lung ===
			<peir-vm>UAB-Histology-00107</peir-vm>

			=== Skin: Scleroderma ===
	<peir-vm>IPLab6Scleroderma_Skin</peir-vm>		<peir-vm>IPLab6Scleroderma_Skin</peir-vm>

			=== Normal Skin ===
			<peir-vm>UAB-Histology-00004</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park at 20:38, 21 February 2014

2014-02-21T20:38:55Z

← Older revision		Revision as of 15:38, 21 February 2014
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	== Virtual Microscopy ==		== Virtual Microscopy ==
			=== Lung ===
			<peir-vm>IPLab6Scleroderma</peir-vm>

	=== Skin ===		=== Skin ===
	<peir-vm>IPLab6Scleroderma_Skin</peir-vm>		<peir-vm>IPLab6Scleroderma_Skin</peir-vm>

Seung Park: /* Virtual Microscopy */

2014-01-03T16:18:31Z

Virtual Microscopy

← Older revision		Revision as of 11:18, 3 January 2014
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	== Virtual Microscopy ==		== Virtual Microscopy ==
			=== Skin ===
	<peir-vm>IPLab6Scleroderma_Skin</peir-vm>		<peir-vm>IPLab6Scleroderma_Skin</peir-vm>

Seung Park: /* Virtual Microscopy */

2014-01-03T16:18:10Z

Virtual Microscopy

← Older revision		Revision as of 11:18, 3 January 2014
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	== Virtual Microscopy ==		== Virtual Microscopy ==
	<peir-vm>~~IPLab6Scleroderma~~</peir-vm>		<peir-vm>IPLab6Scleroderma_Skin</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park at 16:17, 3 January 2014

2014-01-03T16:17:52Z

← Older revision		Revision as of 11:17, 3 January 2014
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	File:IPLab6Scleroderma5.jpg\|This is a gross photograph of the heart from this case. There is thickening of the left ventricular wall and some thickening of the right ventricle as well.		File:IPLab6Scleroderma5.jpg\|This is a gross photograph of the heart from this case. There is thickening of the left ventricular wall and some thickening of the right ventricle as well.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab6Scleroderma</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Journal Articles */

2013-08-30T01:35:39Z

Journal Articles

← Older revision		Revision as of 20:35, 29 August 2013
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	* [http://emedicine.medscape.com/article/1064663-overview eMedicine Medical Library: CREST Syndrome]		* [http://emedicine.medscape.com/article/1064663-overview eMedicine Medical Library: CREST Syndrome]
	* [http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/systemic_sclerosis.html Merck Manual: Systemic Sclerosis]		* [http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/systemic_sclerosis.html Merck Manual: Systemic Sclerosis]

	~~=== Journal Articles ===~~


	=== Images ===		=== Images ===

Seung Park: /* Images */

2013-08-30T01:35:31Z

Images

← Older revision		Revision as of 20:35, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir,path.uab.edu~~/library/index.php?/tags/2144-scleroderma PEIR Digital Library: Scleroderma Images]		* [{{SERVER}}/library/index.php?/tags/2144-scleroderma PEIR Digital Library: Scleroderma Images]

	== Related IPLab Cases ==		== Related IPLab Cases ==

Seung Park: /* Related IPLab Cases */

2013-08-22T23:49:22Z

Related IPLab Cases

← Older revision		Revision as of 18:49, 22 August 2013
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	== Related IPLab Cases ==		== Related IPLab Cases ==
	* [[IPLab:Lab 2:Hypertrophy\|Lab 2: Heart: Myocardial Hypertrophy]]		* [[IPLab:Lab 2:Hypertrophy\|Lab 2: Heart: Myocardial Hypertrophy]]
	* [[IPLab:Lab 5:α 1 Antitrypsin Deficiency\|Lab 5: Lung: ~~Alpha~~ 1-Antitrypsin Deficiency]]		* [[IPLab:Lab 5:α1 Antitrypsin Deficiency\|Lab 5: Lung: α1-Antitrypsin Deficiency]]

	{{IPLab 6}}		{{IPLab 6}}

	[[Category: IPLab:Lab 6]]		[[Category: IPLab:Lab 6]]