IPLab:Lab 6:Acute Rejection - Revision history

Peter Anderson: /* Images */

2020-07-08T23:46:26Z

‎Images

Peter Anderson: /* Autopsy Findings */

2020-07-08T23:42:08Z

‎Autopsy Findings

Peter Anderson: /* Clinical Summary */

2020-07-08T23:42:00Z

‎Clinical Summary

Seung Park at 16:19, 3 January 2014

2014-01-03T16:19:50Z

Seung Park: /* Images */

2013-08-30T01:36:16Z

‎Images

Seung Park: /* Reference */

2013-08-23T04:00:13Z

‎Reference

Seung Park: /* Related IPLab Cases */

2013-08-23T03:56:36Z

‎Related IPLab Cases

Seung Park: /* Images */

2013-08-23T03:55:40Z

‎Images

Seung Park: /* Journal Articles */

2013-08-23T03:54:24Z

‎Journal Articles

Seung Park at 03:53, 23 August 2013

2013-08-23T03:53:41Z

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 File:IPLab6AcuteRejection1.jpg|This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.
 File:IPLab6AcuteRejection2.jpg|This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney parenchyma.
 File:IPLab6AcuteRejection4.jpg|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.
 File:IPLab6AcuteRejection5.jpg|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.
 File:IPLab6AcuteRejection6.jpg|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.
 File:IPLab6AcuteRejection8.jpg|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium (1) and in the wall of the blood vessel (2).
 File:IPLab6AcuteRejection9.jpg|This is a high-power photomicrograph of cells infiltrating the wall of the blood vessel.

← Older revision		Revision as of 23:42, 8 July 2020
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	The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.		The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.
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−	~~== Autopsy Findings ==~~
−	The kidney weighed 240 grams and was edematous. The capsule stripped with ease to reveal a pale tan-brown cortex which was irregularly red-mottled. Upon sectioning, the cortical band was ill-defined, and the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis displayed generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

	== Images ==		== Images ==

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 == Clinical Summary ==
-This 34-year-old white male with end-stage chronic glomerulonephritis had been receiving hemodialysis three times per week for 4 months when he was admitted to the hospital for a living related-donor transplantation from his mother. Other than the kidney disease, the patient was in good health. The transplant was performed successfully with no complications. However, eight days later, transplant rejection necessitated returning the patient to the operating room for a nephrectomy of the transplanted kidney. After the nephrectomy, the patient did quite well, was returned to hemodialysis, and was discharged home in good condition.
+This 34-year-old male with end-stage chronic glomerulonephritis had been receiving hemodialysis for 4 months when he received a  living related-donor transplantation from his mother. The transplant was successfully with no complications. However, eight days later, transplant rejection necessitated removal of the transplanted kidney.  After the nephrectomy, the patient did well and was returned to hemodialysis.
 == Autopsy Findings ==

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 File:IPLab6AcuteRejection10.jpg|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and cells within the renal tubules.
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
+* [{{SERVER}}/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
 * [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]

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 * [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
 * [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]
-* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephritic Syndrome]
+* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephrotic Syndrome]
 * [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]
 * [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]

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 == Related IPLab Cases ==
+* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

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 === Journal Articles ===
+* Matas AJ.  [http://www.ncbi.nlm.nih.gov/pubmed/11272615 Impact of acute rejection on development of chronic rejection in pediatric renal transplant recipients].  ''Pediatr Transplant'' 2000 May;4(2):92-9.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
 === Journal Articles ===