IPLab:Lab 6:Acute Rejection - Revision history

Peter Anderson: /* Images */

2020-07-08T23:46:26Z

Images

← Older revision		Revision as of 18:46, 8 July 2020
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	File:IPLab6AcuteRejection1.jpg\|This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.		File:IPLab6AcuteRejection1.jpg\|This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.
	File:IPLab6AcuteRejection2.jpg\|This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney parenchyma.		File:IPLab6AcuteRejection2.jpg\|This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney parenchyma.
	~~File:IPLab6AcuteRejection3.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section.~~
	File:IPLab6AcuteRejection4.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.		File:IPLab6AcuteRejection4.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.
	File:IPLab6AcuteRejection5.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.		File:IPLab6AcuteRejection5.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.
	File:IPLab6AcuteRejection6.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.		File:IPLab6AcuteRejection6.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.
	~~File:IPLab6AcuteRejection7.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and in the wall of the blood vessel on the left.~~
	File:IPLab6AcuteRejection8.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium (1) and in the wall of the blood vessel (2).		File:IPLab6AcuteRejection8.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium (1) and in the wall of the blood vessel (2).
	File:IPLab6AcuteRejection9.jpg\|This is a high-power photomicrograph of cells infiltrating the wall of the blood vessel.		File:IPLab6AcuteRejection9.jpg\|This is a high-power photomicrograph of cells infiltrating the wall of the blood vessel.

Peter Anderson: /* Autopsy Findings */

2020-07-08T23:42:08Z

Autopsy Findings

← Older revision		Revision as of 18:42, 8 July 2020
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	The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.		The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

	~~== Autopsy Findings ==~~
	The kidney weighed 240 grams and was edematous. The capsule stripped with ease to reveal a pale tan-brown cortex which was irregularly red-mottled. Upon sectioning, the cortical band was ill-defined, and the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis displayed generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-07-08T23:42:00Z

Clinical Summary

← Older revision		Revision as of 18:42, 8 July 2020
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	== Clinical Summary ==		== Clinical Summary ==
	This 34-year-old ~~white~~ male with end-stage chronic glomerulonephritis had been receiving hemodialysis ~~three times per week~~ for 4 months when he ~~was admitted to the hospital for~~ a living related-donor transplantation from his mother~~. Other than the kidney disease, the patient was in good health~~. The transplant was ~~performed~~ successfully with no complications. However, eight days later, transplant rejection necessitated ~~returning the patient to the operating room for a nephrectomy~~ of the transplanted kidney. After the nephrectomy, the patient did ~~quite~~ well, was returned to hemodialysis, and was ~~discharged home in good condition~~.		This 34-year-old male with end-stage chronic glomerulonephritis had been receiving hemodialysis for 4 months when he received a living related-donor transplantation from his mother. The transplant was successfully with no complications. However, eight days later, transplant rejection necessitated removal of the transplanted kidney. After the nephrectomy, the patient did well and was returned to hemodialysis.

			The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

	== Autopsy Findings ==		== Autopsy Findings ==

Seung Park at 16:19, 3 January 2014

2014-01-03T16:19:50Z

← Older revision		Revision as of 11:19, 3 January 2014
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	File:IPLab6AcuteRejection10.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and cells within the renal tubules.		File:IPLab6AcuteRejection10.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and cells within the renal tubules.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab6AcuteRejection</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Images */

2013-08-30T01:36:16Z

Images

← Older revision		Revision as of 20:36, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]		* [{{SERVER}}/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
	* [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]		* [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]

Seung Park: /* Reference */

2013-08-23T04:00:13Z

Reference

← Older revision		Revision as of 23:00, 22 August 2013
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	* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]		* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
	* [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]		* [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]
	* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: ~~Nephritic~~ Syndrome]		* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephrotic Syndrome]
	* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]		* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]
	* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]		* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]

Seung Park: /* Related IPLab Cases */

2013-08-23T03:56:36Z

Related IPLab Cases

← Older revision		Revision as of 22:56, 22 August 2013
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	== Related IPLab Cases ==		== Related IPLab Cases ==
			* [[IPLab:Lab 1:Kidney Infarction\|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
			* [[IPLab:Lab 6:Chronic Rejection\|Lab 6: Kidney: Chronic Transplant Rejection]]
			* [[IPLab:Lab 10:Candidiasis\|Lab 10: Kidney: Candidiasis]]

	{{IPLab 6}}		{{IPLab 6}}

	[[Category: IPLab:Lab 6]]		[[Category: IPLab:Lab 6]]

Seung Park: /* Images */

2013-08-23T03:55:40Z

Images

← Older revision		Revision as of 22:55, 22 August 2013
Line 36:		Line 36:

	=== Images ===		=== Images ===
			* [http://peir.path.uab.edu/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
			* [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]

	== Related IPLab Cases ==		== Related IPLab Cases ==

Seung Park: /* Journal Articles */

2013-08-23T03:54:24Z

Journal Articles

← Older revision		Revision as of 22:54, 22 August 2013
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	=== Journal Articles ===		=== Journal Articles ===
			* Matas AJ. [http://www.ncbi.nlm.nih.gov/pubmed/11272615 Impact of acute rejection on development of chronic rejection in pediatric renal transplant recipients]. ''Pediatr Transplant'' 2000 May;4(2):92-9.

	=== Images ===		=== Images ===

Seung Park at 03:53, 23 August 2013

2013-08-23T03:53:41Z

← Older revision		Revision as of 22:53, 22 August 2013
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	== Additional Resources ==		== Additional Resources ==
	=== Reference ===		=== Reference ===
			* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
			* [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]
			* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephritic Syndrome]
			* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]
			* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]
			* [http://www.merckmanuals.com/professional/immunology_allergic_disorders/transplantation/kidney_transplantation.html Merck Manual: Kidney Transplantation]

	=== Journal Articles ===		=== Journal Articles ===

← Older revision		Revision as of 18:46, 8 July 2020
Line 8:		Line 8:
	File:IPLab6AcuteRejection1.jpg\|This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.		File:IPLab6AcuteRejection1.jpg\|This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.
	File:IPLab6AcuteRejection2.jpg\|This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney parenchyma.		File:IPLab6AcuteRejection2.jpg\|This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney parenchyma.
	~~File:IPLab6AcuteRejection3.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section.~~
	File:IPLab6AcuteRejection4.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.		File:IPLab6AcuteRejection4.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.
	File:IPLab6AcuteRejection5.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.		File:IPLab6AcuteRejection5.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.
	File:IPLab6AcuteRejection6.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.		File:IPLab6AcuteRejection6.jpg\|This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.
	~~File:IPLab6AcuteRejection7.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and in the wall of the blood vessel on the left.~~
	File:IPLab6AcuteRejection8.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium (1) and in the wall of the blood vessel (2).		File:IPLab6AcuteRejection8.jpg\|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium (1) and in the wall of the blood vessel (2).
	File:IPLab6AcuteRejection9.jpg\|This is a high-power photomicrograph of cells infiltrating the wall of the blood vessel.		File:IPLab6AcuteRejection9.jpg\|This is a high-power photomicrograph of cells infiltrating the wall of the blood vessel.