IPLab:Lab 3:Healed Myocardial Infarction - Revision history

Peter Anderson: /* Images */

2020-06-24T01:36:55Z

Images

← Older revision		Revision as of 20:36, 23 June 2020
Line 6:		Line 6:
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">
	File:~~IPLab3HealedMyocardialInfarction1~~.jpg\|This is a gross photograph of a heart with areas of old healed myocardial infarction (scars) outlined by arrows.		File:IPLab3HealedMyocardialInfarction1b.jpg\|This is a gross photograph of a heart with areas of old healed myocardial infarction (scars) outlined by arrows.
	File:~~IPLab3HealedMyocardialInfarction2~~.jpg\|This is a low-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is on the ~~left~~ (1) and the fibrous connective tissue scar is on the ~~right~~ (2).		File:IPLab3HealedMyocardialInfarction2b.jpg\|This is a low-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is on the right (1) and the fibrous connective tissue scar is on the left (2).
	File:~~IPLab3HealedMyocardialInfarction3~~.jpg\|This is a higher-power photomicrograph of a healed myocardial infarction with a fibrous scar. ~~Remaining~~ normal tissue is at the ~~top~~ (1) and the fibrous connective tissue scar is at the ~~bottom~~ (2~~). Note the presence of occasional hypereosinophilic myocytes indicating recent acute ischemic injury to this region of old scar tissue (arrows~~).		File:IPLab3HealedMyocardialInfarction3b.jpg\|This is a higher-power photomicrograph of the healed myocardial infarction with a fibrous scar. The normal tissue is on the right (1) and the fibrous connective tissue scar is on the upper left (2).
	File:~~IPLab3HealedMyocardialInfarction4~~.jpg\|This is ~~another high~~-power photomicrograph of a healed myocardial infarction. ~~Note~~ the ~~remaining normal myocytes~~ (1), the fibrous connective tissue (2)~~, and~~ occasional hypereosinophilic myocytes indicating recent acute ischemic injury ~~(arrow)~~.		File:IPLab3HealedMyocardialInfarction4b.jpg\|This is a higher-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is at the right (1) and the fibrous connective tissue scar is at the left (2). Note the presence of occasional hypereosinophilic myocytes (arrows) indicating recent acute ischemic injury to this region of old scar tissue.
	File:~~IPLab3HealedMyocardialInfarction5~~.jpg\|This is a low-power photomicrograph ~~of two sections~~ of myocardial tissue stained with a trichrome stain to demonstrate fibrous connective tissue (blue). The section on the ~~left is from a heart with a recent myocardial infarction. Notice the absence of~~ fibrous connective tissue~~. The section on the right is~~ from a heart with an old healed infarct ~~and it contains extensive fibrous connective tissue scars.~~		File:IPLab3HealedMyocardialInfarction5bs.jpg\|This is a low-power photomicrograph of myocardial tissue stained with a trichrome stain to demonstrate fibrous connective tissue (blue-green). The section shows the mature fibrous connective tissue from this heart with an old healed infarct. Some viable myocardial tissue remains (arrows).
	~~File:IPLab3HealedMyocardialInfarction6~~.~~jpg\|This is a photomicrograph of a trichrome-stained section from a heart with an acute~~ myocardial ~~infarction. Note that there is little fibrous connective~~ tissue~~. It is too early for scar formation to have taken place in this acute lesion~~.		File:IPLab3HealedMyocardialInfarction6bs.jpg\|This is a photomicrograph of a trichrome-stained section of heart containing an old healed myocardial infarction. The scar is composed of mature fibrous connective tissue (blue-green) and some remaining viable myocytes (red). A small focus of adipose tissue can be seen in the scar (arrow).
	File:~~IPLab3HealedMyocardialInfarction7~~.jpg\|This is a photomicrograph of a trichrome-stained section of heart containing an old healed myocardial infarction. The scar is composed of mature fibrous connective tissue (~~arrows~~).
	~~File:IPLab3HealedMyocardialInfarction8.jpg\|This is a higher-power photomicrograph~~ of ~~a trichrome-stained section of heart containing an old healed MI. The~~ scar ~~tissue~~ (~~mature fibrous connective tissue~~) ~~is stained blue~~.
	</gallery>		</gallery>

Peter Anderson: /* Autopsy Findings */

2020-06-24T01:16:40Z

Autopsy Findings

← Older revision		Revision as of 20:16, 23 June 2020
Line 3:		Line 3:

	Autopsy showed a 340-gram heart with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowing of all coronary arteries and an acute thrombus in the left anterior descending. The lungs showed pulmonary edema and early bronchopneumonia.		Autopsy showed a 340-gram heart with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowing of all coronary arteries and an acute thrombus in the left anterior descending. The lungs showed pulmonary edema and early bronchopneumonia.

	~~== Autopsy Findings ==~~
	Autopsy showed a 340-gram heart with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowing of all coronary arteries especially the left anterior descending. The lungs showed pulmonary edema and early bronchopneumonia.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-06-24T01:16:27Z

Clinical Summary

← Older revision		Revision as of 20:16, 23 June 2020
Line 1:		Line 1:
	== Clinical Summary ==		== Clinical Summary ==
	This 37-year-old white female with a 22 year history of insulin-dependent diabetes was admitted to the hospital 10 hours prior to death complaining of ~~chest pain and~~ shortness of breath. Three months before, she had begun to experience progressive weakness and for the previous 3 weeks she noticed increasing dyspnea on exertion and worsening of a chronic cough.		This 57-year-old white female with a 22 year history of insulin-dependent diabetes was admitted to the hospital 10 hours prior to death complaining of shortness of breath. Three months before, she had begun to experience progressive weakness and for the previous 3 weeks she noticed increasing dyspnea on exertion and worsening of a chronic cough. Despite appropriate care she developed an intractable arrhythmia and could not be resuscitated.

			Autopsy showed a 340-gram heart with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowing of all coronary arteries and an acute thrombus in the left anterior descending. The lungs showed pulmonary edema and early bronchopneumonia.

	== Autopsy Findings ==		== Autopsy Findings ==

Seung Park at 16:09, 3 January 2014

2014-01-03T16:09:47Z

← Older revision		Revision as of 11:09, 3 January 2014
Line 16:		Line 16:
	File:IPLab3HealedMyocardialInfarction8.jpg\|This is a higher-power photomicrograph of a trichrome-stained section of heart containing an old healed MI. The scar tissue (mature fibrous connective tissue) is stained blue.		File:IPLab3HealedMyocardialInfarction8.jpg\|This is a higher-power photomicrograph of a trichrome-stained section of heart containing an old healed MI. The scar tissue (mature fibrous connective tissue) is stained blue.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			=== Early (Inflammatory Response) ===
			<peir-vm>IPLab3HealedMyocardialInfarction_A</peir-vm>

			=== Late (Replacement Fibrosis) ===
			<peir-vm>IPLab3HealedMyocardialInfarction</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Images */

2013-08-30T01:28:04Z

Images

← Older revision		Revision as of 20:28, 29 August 2013
Line 37:		Line 37:

	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/43-myocardial_infarct PEIR Digital Library: Myocardial Infarct Images]		* [{{SERVER}}/library/index.php?/tags/43-myocardial_infarct PEIR Digital Library: Myocardial Infarct Images]
	* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]		* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]

Seung Park: /* Related IPLab Cases */

2013-08-22T02:19:48Z

Related IPLab Cases

← Older revision		Revision as of 21:19, 21 August 2013
Line 40:		Line 40:
	* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]		* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]

	=== Related IPLab Cases ===		== Related IPLab Cases ==
	* [[IPLab:Lab 1:Myocardial Infarction\|Lab 1: Heart: Myocardial Infarction (Coagulative Necrosis)]]		* [[IPLab:Lab 1:Myocardial Infarction\|Lab 1: Heart: Myocardial Infarction (Coagulative Necrosis)]]
	* [[IPLab:Lab 3:Acute Myocardial Infarction\|Lab 3: Heart: Acute Myocardial Infarction]]		* [[IPLab:Lab 3:Acute Myocardial Infarction\|Lab 3: Heart: Acute Myocardial Infarction]]

Seung Park: /* Journal Articles */

2013-08-21T22:36:19Z

Journal Articles

← Older revision		Revision as of 17:36, 21 August 2013
Line 34:		Line 34:

	=== Journal Articles ===		=== Journal Articles ===
			* Yuan S, Liu Y, Zhu L. [http://www.ncbi.nlm.nih.gov/pubmed/10626065 Vascular complications of diabetes mellitus]. ''Clin Exp Pharmacol Physiol'' 1999 Dec;26(12):977-8.

	=== Images ===		=== Images ===

Seung Park: /* Related IPLab Cases */

2013-08-21T22:34:59Z

Related IPLab Cases

← Older revision		Revision as of 17:34, 21 August 2013
Line 41:		Line 41:

	=== Related IPLab Cases ===		=== Related IPLab Cases ===
			* [[IPLab:Lab 1:Myocardial Infarction\|Lab 1: Heart: Myocardial Infarction (Coagulative Necrosis)]]
			* [[IPLab:Lab 3:Acute Myocardial Infarction\|Lab 3: Heart: Acute Myocardial Infarction]]
			* [[IPLab:Lab 4:Mural Thrombus\|Lab 4: Heart: Mural Thrombus]]
			* [[IPLab:Lab 4:Thrombosis\|Lab 4: Coronary Artery: Thrombosis]]
			* [[IPLab:Lab 4:Pulmonary Congestion and Edema\|Lab 4: Lung: Pulmonary Congestion and Edema]]

	{{IPLab 3}}		{{IPLab 3}}

	[[Category: IPLab:Lab 3]]		[[Category: IPLab:Lab 3]]

Seung Park: /* Images */

2013-08-21T22:34:21Z

Images

← Older revision		Revision as of 17:34, 21 August 2013
Line 37:		Line 37:

	=== Images ===		=== Images ===
			* [http://peir.path.uab.edu/library/index.php?/tags/43-myocardial_infarct PEIR Digital Library: Myocardial Infarct Images]
			* [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]

	=== Related IPLab Cases ===		=== Related IPLab Cases ===

Seung Park: /* Reference */

2013-08-21T22:33:55Z

Reference

← Older revision		Revision as of 17:33, 21 August 2013
Line 30:		Line 30:
	== Additional Resources ==		== Additional Resources ==
	=== Reference ===		=== Reference ===
			* [http://emedicine.medscape.com/article/155919-overview eMedicine Medical Library: Myocardial Infarction]
			* [http://www.merckmanuals.com/professional/cardiovascular_disorders/coronary_artery_disease/acute_coronary_syndromes_acs.html Merck Manual: Acute Coronary Syndromes]

	=== Journal Articles ===		=== Journal Articles ===

← Older revision		Revision as of 20:36, 23 June 2020
Line 6:		Line 6:
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">
	File:~~IPLab3HealedMyocardialInfarction1~~.jpg\|This is a gross photograph of a heart with areas of old healed myocardial infarction (scars) outlined by arrows.		File:IPLab3HealedMyocardialInfarction1b.jpg\|This is a gross photograph of a heart with areas of old healed myocardial infarction (scars) outlined by arrows.
	File:~~IPLab3HealedMyocardialInfarction2~~.jpg\|This is a low-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is on the ~~left~~ (1) and the fibrous connective tissue scar is on the ~~right~~ (2).		File:IPLab3HealedMyocardialInfarction2b.jpg\|This is a low-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is on the right (1) and the fibrous connective tissue scar is on the left (2).
	File:~~IPLab3HealedMyocardialInfarction3~~.jpg\|This is a higher-power photomicrograph of a healed myocardial infarction with a fibrous scar. ~~Remaining~~ normal tissue is at the ~~top~~ (1) and the fibrous connective tissue scar is at the ~~bottom~~ (2~~). Note the presence of occasional hypereosinophilic myocytes indicating recent acute ischemic injury to this region of old scar tissue (arrows~~).		File:IPLab3HealedMyocardialInfarction3b.jpg\|This is a higher-power photomicrograph of the healed myocardial infarction with a fibrous scar. The normal tissue is on the right (1) and the fibrous connective tissue scar is on the upper left (2).
	File:~~IPLab3HealedMyocardialInfarction4~~.jpg\|This is ~~another high~~-power photomicrograph of a healed myocardial infarction. ~~Note~~ the ~~remaining normal myocytes~~ (1), the fibrous connective tissue (2)~~, and~~ occasional hypereosinophilic myocytes indicating recent acute ischemic injury ~~(arrow)~~.		File:IPLab3HealedMyocardialInfarction4b.jpg\|This is a higher-power photomicrograph of a healed myocardial infarction with a fibrous scar. Remaining normal tissue is at the right (1) and the fibrous connective tissue scar is at the left (2). Note the presence of occasional hypereosinophilic myocytes (arrows) indicating recent acute ischemic injury to this region of old scar tissue.
	File:~~IPLab3HealedMyocardialInfarction5~~.jpg\|This is a low-power photomicrograph ~~of two sections~~ of myocardial tissue stained with a trichrome stain to demonstrate fibrous connective tissue (blue). The section on the ~~left is from a heart with a recent myocardial infarction. Notice the absence of~~ fibrous connective tissue~~. The section on the right is~~ from a heart with an old healed infarct ~~and it contains extensive fibrous connective tissue scars.~~		File:IPLab3HealedMyocardialInfarction5bs.jpg\|This is a low-power photomicrograph of myocardial tissue stained with a trichrome stain to demonstrate fibrous connective tissue (blue-green). The section shows the mature fibrous connective tissue from this heart with an old healed infarct. Some viable myocardial tissue remains (arrows).
	~~File:IPLab3HealedMyocardialInfarction6~~.~~jpg\|This is a photomicrograph of a trichrome-stained section from a heart with an acute~~ myocardial ~~infarction. Note that there is little fibrous connective~~ tissue~~. It is too early for scar formation to have taken place in this acute lesion~~.		File:IPLab3HealedMyocardialInfarction6bs.jpg\|This is a photomicrograph of a trichrome-stained section of heart containing an old healed myocardial infarction. The scar is composed of mature fibrous connective tissue (blue-green) and some remaining viable myocytes (red). A small focus of adipose tissue can be seen in the scar (arrow).
	File:~~IPLab3HealedMyocardialInfarction7~~.jpg\|This is a photomicrograph of a trichrome-stained section of heart containing an old healed myocardial infarction. The scar is composed of mature fibrous connective tissue (~~arrows~~).
	~~File:IPLab3HealedMyocardialInfarction8.jpg\|This is a higher-power photomicrograph~~ of ~~a trichrome-stained section of heart containing an old healed MI. The~~ scar ~~tissue~~ (~~mature fibrous connective tissue~~) ~~is stained blue~~.
	</gallery>		</gallery>