IPLab:Lab 3:Acute Myocardial Infarction - Revision history

Peter Anderson: /* Images */

2020-06-24T01:14:31Z

‎Images

Peter Anderson: /* Images */

2020-06-24T00:48:51Z

‎Images

Peter Anderson: /* Images */

2020-06-24T00:38:58Z

‎Images

Peter Anderson: /* Images */

2020-06-24T00:25:33Z

‎Images

Peter Anderson: /* Clinical Summary */

2020-06-20T00:14:25Z

‎Clinical Summary

Peter Anderson: /* Autopsy Findings */

2020-06-20T00:13:31Z

‎Autopsy Findings

Peter Anderson: /* Clinical Summary */

2020-06-20T00:13:18Z

‎Clinical Summary

Peter Anderson: /* Virtual Microscopy */

2015-09-17T19:45:16Z

‎Virtual Microscopy

Seung Park at 16:08, 3 January 2014

2014-01-03T16:08:54Z

Seung Park: /* Images */

2013-08-30T01:27:54Z

‎Images

@@ Line 8: / Line 8: @@
 File:IPLab3AcuteMyocardialInfarction1a.JPG|This is a gross photo of the heart at autopsy after the left ventricle was opened.  Note the thrombotic material (T) that is present within the left ventricular lumen over the area of infarction. On the cut edge of the left ventricular free wall you can see the areas of hemorrhage and the pale myocardium indicative of an acute myocardial infarction (arrows).
 File:IPLab3AcuteMyocardialInfarction1bf.jpg|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (T) adherent to the endocardial surface.
-File:IPLab3AcuteMyocardialInfarction2b.jpg|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
+File:IPLab3AcuteMyocardialInfarction2bs.jpg|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (Epi), the blue line of inflammatory cells (arrows) with the infarcted myocardium below.
-File:IPLab3AcuteMyocardialInfarction3b.JPG|This is a photomicrograph of the edge of the infarct with normal tissue on the left (1). The accumulation of inflammatory cells (2) is at the edge of the infarcted tissue (3).
+File:IPLab3AcuteMyocardialInfarction3b.jpg|This is a photomicrograph of the edge of the infarct with normal tissue above and infarcted tissue below the line of inflammatory cells (arrow).
-File:IPLab3AcuteMyocardialInfarction4b.JPG|This is a higher-power photomicrograph of the edge of the infarct. The accumulation of inflammatory cells is on the left (1) and the infarcted tissue is on the right (2). Note that intact cells can be seen in the infarct but there are no nuclei.
+File:IPLab3AcuteMyocardialInfarction4b.jpg|This is a higher-power photomicrograph of infarcted tissue just below the line of inflammatory cells. The myocytes have lost their nuclei and the cytoplasm has a granular appearance indicating that this is coagulation necrosis.
-File:IPLab3AcuteMyocardialInfarction5b.JPG|This is a high-power photomicrograph of another area of this section. There are several hypereosinophilic cells within this section (arrows).
+File:IPLab3AcuteMyocardialInfarction5b.jpg|This is a high-power photomicrograph of he inflammatory cells present at the border zone between normal and infarcted tissue. Many of the inflammatory cells have begun to die and break down (note blue tinge to tissue) but viable nutrophils and some lymphocutes and macrophages are visible.
 File:IPLab3AcuteMyocardialInfarction6.jpg|This is a low-power photomicrograph of a mural thrombus (1) adherent to the endocardial surface (arrows).
 File:IPLab3AcuteMyocardialInfarction7.jpg|This is a photomicrograph of the lines of Zahn. Pale areas (1) represent platelets with some fibrin and the darker lines (2) represent RBCs and leukocytes enmeshed in fibrin strands.

@@ Line 6: / Line 6: @@
 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab3AcuteMyocardialInfarction1a.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.
+File:IPLab3AcuteMyocardialInfarction1a.JPG|This is a gross photo of the heart at autopsy after the left ventricle was opened.  Note the thrombotic material (T) that is present within the left ventricular lumen over the area of infarction. On the cut edge of the left ventricular free wall you can see the areas of hemorrhage and the pale myocardium indicative of an acute myocardial infarction (arrows).
-File:IPLab3AcuteMyocardialInfarction1bf.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.File:IPLab3AcuteMyocardialInfarction2b.JPG|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
+File:IPLab3AcuteMyocardialInfarction1bf.jpg|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (T) adherent to the endocardial surface.
 File:IPLab3AcuteMyocardialInfarction3b.JPG|This is a photomicrograph of the edge of the infarct with normal tissue on the left (1). The accumulation of inflammatory cells (2) is at the edge of the infarcted tissue (3).
 File:IPLab3AcuteMyocardialInfarction4b.JPG|This is a higher-power photomicrograph of the edge of the infarct. The accumulation of inflammatory cells is on the left (1) and the infarcted tissue is on the right (2). Note that intact cells can be seen in the infarct but there are no nuclei.

@@ Line 7: / Line 7: @@
 <gallery heights="250px" widths="250px">
 File:IPLab3AcuteMyocardialInfarction1a.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.
-File:IPLab3AcuteMyocardialInfarction1b.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.File:IPLab3AcuteMyocardialInfarction2b.JPG|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
+File:IPLab3AcuteMyocardialInfarction1bf.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.File:IPLab3AcuteMyocardialInfarction2b.JPG|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
 File:IPLab3AcuteMyocardialInfarction3b.JPG|This is a photomicrograph of the edge of the infarct with normal tissue on the left (1). The accumulation of inflammatory cells (2) is at the edge of the infarcted tissue (3).
 File:IPLab3AcuteMyocardialInfarction4b.JPG|This is a higher-power photomicrograph of the edge of the infarct. The accumulation of inflammatory cells is on the left (1) and the infarcted tissue is on the right (2). Note that intact cells can be seen in the infarct but there are no nuclei.

@@ Line 6: / Line 6: @@
 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab3AcuteMyocardialInfarction1.jpg|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.
+File:IPLab3AcuteMyocardialInfarction1a.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.
-File:IPLab3AcuteMyocardialInfarction2.jpg|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
+File:IPLab3AcuteMyocardialInfarction1b.JPG|This is a low-power photomicrograph of infarcted heart. There is a layer of surviving myocardial tissue (1) along the epicardium and then a blue line (2) which represents the accumulation of inflammatory cells at the border of the infarct. There is thrombotic material (3) adherent to the endocardial surface.File:IPLab3AcuteMyocardialInfarction2b.JPG|This is a higher-power photomicrograph which shows more clearly the viable tissue along the epicardium (1), the blue line of inflammatory cells (2), and the infarcted myocardium (3).
-File:IPLab3AcuteMyocardialInfarction3.jpg|This is a photomicrograph of the edge of the infarct with normal tissue on the left (1). The accumulation of inflammatory cells (2) is at the edge of the infarcted tissue (3).
+File:IPLab3AcuteMyocardialInfarction3b.JPG|This is a photomicrograph of the edge of the infarct with normal tissue on the left (1). The accumulation of inflammatory cells (2) is at the edge of the infarcted tissue (3).
-File:IPLab3AcuteMyocardialInfarction4.jpg|This is a higher-power photomicrograph of the edge of the infarct. The accumulation of inflammatory cells is on the left (1) and the infarcted tissue is on the right (2). Note that intact cells can be seen in the infarct but there are no nuclei.
+File:IPLab3AcuteMyocardialInfarction4b.JPG|This is a higher-power photomicrograph of the edge of the infarct. The accumulation of inflammatory cells is on the left (1) and the infarcted tissue is on the right (2). Note that intact cells can be seen in the infarct but there are no nuclei.
-File:IPLab3AcuteMyocardialInfarction5.jpg|This is a high-power photomicrograph of another area of this section. There are several hypereosinophilic cells within this section (arrows).
+File:IPLab3AcuteMyocardialInfarction5b.JPG|This is a high-power photomicrograph of another area of this section. There are several hypereosinophilic cells within this section (arrows).
 File:IPLab3AcuteMyocardialInfarction6.jpg|This is a low-power photomicrograph of a mural thrombus (1) adherent to the endocardial surface (arrows).
 File:IPLab3AcuteMyocardialInfarction7.jpg|This is a photomicrograph of the lines of Zahn. Pale areas (1) represent platelets with some fibrin and the darker lines (2) represent RBCs and leukocytes enmeshed in fibrin strands.

@@ Line 1: / Line 1: @@
 == Clinical Summary ==
 This 78-year-old male experienced a posterior myocardial infarction six years prior to this admission. Recently, he had begun to experience occasional angina. Four days prior to death, he experienced anterior chest pain and discomfort which he regarded as not too distressing. However, EKGs showed a classic acute anterior myocardial infarction in addition to the healed posterior infarct. His bloodwork also showed an elevated troponin. The patient progressively deteriorated with signs of left ventricular failure and died with arrhythmias and pulmonary edema.
 == Images ==

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 == Virtual Microscopy ==
 <peir-vm>IPLab3AcuteMyocardialInfarction</peir-vm>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/43-myocardial_infarct PEIR Digital Library: Myocardial Infarct Images]
+* [{{SERVER}}/library/index.php?/tags/43-myocardial_infarct PEIR Digital Library: Myocardial Infarct Images]
 * [http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html WebPath: Cardiovascular Pathology]