IPLab:Lab 1:Tuberculosis - Revision history

Peter Anderson: /* Images */

2019-06-27T22:09:14Z

Images

← Older revision		Revision as of 17:09, 27 June 2019
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	File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.		File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.
	File:IPLab1Tuberculosis3.jpg\|This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.		File:IPLab1Tuberculosis3.jpg\|This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.
	File:~~IPLab1Tuberculosis4~~.jpg\|This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the ~~left~~ and the remaining edges are cut edges of the tissue block.		File:IPLab1Tuberculosis4b.jpg\|This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the right and the remaining edges are cut edges of the tissue block.
	File:~~IPLab1Tuberculosis5~~.jpg\|This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.		File:IPLab1Tuberculosis5b.jpg\|This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.
	File:~~IPLab1Tuberculosis6~~.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and ~~occasional~~ multinucleated giant ~~cells~~ around the periphery.		File:IPLab1Tuberculosis6b.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (*) and a rim of lymphocytes, macrophages, and a multinucleated giant cell (arrow) around the periphery.
	File:~~IPLab1Tuberculosis7~~.jpg\|This is a higher-power view of ~~the~~ granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant ~~cells near the center~~ (2), and inflammatory cells around the periphery.		File:IPLab1Tuberculosis7b.jpg\|This is a higher-power view of a granuloma with the amorphous eosinophilic material representing caseation necrosis (*), a giant cell (arrow), and inflammatory cells around the periphery.
	File:IPLab1Tuberculosis8b.jpg\|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.
	</gallery>		</gallery>

Peter Anderson: /* Autopsy Findings */

2019-06-27T22:00:52Z

Autopsy Findings

← Older revision		Revision as of 17:00, 27 June 2019
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	Autopsy findings demonstrated pulmonary tuberculosis with widespread dissemination throughout the body. Multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.		Autopsy findings demonstrated pulmonary tuberculosis with widespread dissemination throughout the body. Multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

	~~== Autopsy Findings ==~~
	It was determined at autopsy that the patient suffered from pulmonary tuberculosis with widespread dissemination throughout the body. The left lung weighed 620 grams and the right lung 1230 grams. These were characterized by marked pulmonary congestion and pulmonary edema. In addition, multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2019-06-27T22:00:35Z

Clinical Summary

← Older revision		Revision as of 17:00, 27 June 2019
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	== Clinical Summary ==		== Clinical Summary ==
	This 70-year-old man was admitted to the hospital with a history of upper abdominal pain, anorexia, nausea, and general malaise~~, all of approximately three weeks' duration~~. His hospital stay was characterized by fever and severe respiratory distress. There were multiple densities in the patient's chest x-ray consistent with pneumonia and examination of a stained sputum specimen showed acid fast bacilli. Despite ~~intensive~~ therapy, the patient ~~progressively deteriorated and~~ died 14 days after admission.		This 70-year-old man was admitted to the hospital with a three week history of upper abdominal pain, anorexia, nausea, and general malaise. His hospital stay was characterized by fever and severe respiratory distress. There were multiple densities in the patient's chest x-ray consistent with pneumonia and examination of a stained sputum specimen showed acid fast bacilli. Despite appropriate therapy, the patient died 14 days after admission.

			Autopsy findings demonstrated pulmonary tuberculosis with widespread dissemination throughout the body. Multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

	== Autopsy Findings ==		== Autopsy Findings ==

Peter Anderson: /* Images */

2016-10-31T18:52:33Z

Images

← Older revision		Revision as of 13:52, 31 October 2016
Line 14:		Line 14:
	File:IPLab1Tuberculosis6.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.		File:IPLab1Tuberculosis6.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
	File:IPLab1Tuberculosis7.jpg\|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.		File:IPLab1Tuberculosis7.jpg\|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
	File:~~IPLab1Tuberculosis8~~.jpg\|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.		File:IPLab1Tuberculosis8b.jpg\|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.
	</gallery>		</gallery>

Peter Anderson: /* Images */

2016-10-31T18:48:52Z

Images

← Older revision		Revision as of 13:48, 31 October 2016
Line 14:		Line 14:
	File:IPLab1Tuberculosis6.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.		File:IPLab1Tuberculosis6.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
	File:IPLab1Tuberculosis7.jpg\|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.		File:IPLab1Tuberculosis7.jpg\|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
	File:IPLab1Tuberculosis8.jpg\|This is a high-power photomicrograph of ~~the~~ Langhans-type multinucleated giant ~~cell which is~~ characteristic of tuberculous granulomas ~~(arrow)~~. Note the ~~horseshoe shape~~ of the nuclei in ~~this~~ giant ~~cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining~~ cells ~~in the peripheral portions of this granuloma to the left of which are lymphocytes~~.		File:IPLab1Tuberculosis8.jpg\|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.
	</gallery>		</gallery>

Peter Anderson: /* Virtual Microscopy */

2015-09-16T19:04:02Z

Virtual Microscopy

← Older revision		Revision as of 14:04, 16 September 2015
Line 18:		Line 18:

	== Virtual Microscopy ==		== Virtual Microscopy ==
			=== Lung: Tuberculosis ===
	<peir-vm>IPLab1Tuberculosis</peir-vm>		<peir-vm>IPLab1Tuberculosis</peir-vm>

			=== Normal Lung ===
			<peir-vm>UAB-Histology-00107</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park at 15:38, 3 January 2014

2014-01-03T15:38:07Z

← Older revision		Revision as of 10:38, 3 January 2014
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	File:IPLab1Tuberculosis8.jpg\|This is a high-power photomicrograph of the Langhans-type multinucleated giant cell which is characteristic of tuberculous granulomas (arrow). Note the horseshoe shape of the nuclei in this giant cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining cells in the peripheral portions of this granuloma to the left of which are lymphocytes.		File:IPLab1Tuberculosis8.jpg\|This is a high-power photomicrograph of the Langhans-type multinucleated giant cell which is characteristic of tuberculous granulomas (arrow). Note the horseshoe shape of the nuclei in this giant cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining cells in the peripheral portions of this granuloma to the left of which are lymphocytes.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab1Tuberculosis</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park at 01:23, 30 August 2013

2013-08-30T01:23:01Z

← Older revision		Revision as of 20:23, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/259-tuberculosis PEIR Digital Library: Tuberculosis Images]		* [{{SERVER}}/library/index.php?/tags/259-tuberculosis PEIR Digital Library: Tuberculosis Images]
	* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#4 WebPath: Granulomatous Disease Images]		* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#4 WebPath: Granulomatous Disease Images]

Seung Park at 23:32, 18 August 2013

2013-08-18T23:32:03Z

← Older revision		Revision as of 18:32, 18 August 2013
Line 6:		Line 6:

	== Images ==		== Images ==
	<gallery>		<gallery heights="250px" widths="250px">
	File:IPLab1Tuberculosis1.jpg\|This is a gross photograph of a cut section of lung from this patient with disseminated tuberculosis. The numerous small white nodules scattered throughout this lung tissue represent individual tuberculosis granulomas. In addition, note the dark areas throughout the lung which represent deposits of anthracotic pigment.		File:IPLab1Tuberculosis1.jpg\|This is a gross photograph of a cut section of lung from this patient with disseminated tuberculosis. The numerous small white nodules scattered throughout this lung tissue represent individual tuberculosis granulomas. In addition, note the dark areas throughout the lung which represent deposits of anthracotic pigment.
	File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.		File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.

Seung Park at 05:08, 16 August 2013

2013-08-16T05:08:31Z

← Older revision		Revision as of 00:08, 16 August 2013
Line 6:		Line 6:

	== Images ==		== Images ==
	~~{\| cellpadding="10"~~		<gallery>
	~~\| [[Image~~:IPLab1Tuberculosis1.jpg~~\|frameless]]~~		File:IPLab1Tuberculosis1.jpg\|This is a gross photograph of a cut section of lung from this patient with disseminated tuberculosis. The numerous small white nodules scattered throughout this lung tissue represent individual tuberculosis granulomas. In addition, note the dark areas throughout the lung which represent deposits of anthracotic pigment.
	\| This is a gross photograph of a cut section of lung from this patient with disseminated tuberculosis. The numerous small white nodules scattered throughout this lung tissue represent individual tuberculosis granulomas. In addition, note the dark areas throughout the lung which represent deposits of anthracotic pigment.		File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.
	\|-		File:IPLab1Tuberculosis3.jpg\|This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.
	~~\| [[Image~~:IPLab1Tuberculosis2.jpg~~\|frameless]]~~		File:IPLab1Tuberculosis4.jpg\|This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the left and the remaining edges are cut edges of the tissue block.
	\| This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.		File:IPLab1Tuberculosis5.jpg\|This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.
	\|-		File:IPLab1Tuberculosis6.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
	~~\| [[Image~~:IPLab1Tuberculosis3.jpg~~\|frameless]]~~		File:IPLab1Tuberculosis7.jpg\|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
	\| This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.		File:IPLab1Tuberculosis8.jpg\|This is a high-power photomicrograph of the Langhans-type multinucleated giant cell which is characteristic of tuberculous granulomas (arrow). Note the horseshoe shape of the nuclei in this giant cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining cells in the peripheral portions of this granuloma to the left of which are lymphocytes.
	\|-		</gallery>
	~~\| [[Image~~:IPLab1Tuberculosis4.jpg~~\|frameless]]~~
	\| This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the left and the remaining edges are cut edges of the tissue block.
	\|-
	~~\| [[Image~~:IPLab1Tuberculosis5.jpg~~\|frameless]]~~
	\| This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.
	\|-
	~~\| [[Image~~:IPLab1Tuberculosis6.jpg~~\|frameless]]~~
	\| This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
	\|-
	~~\| [[Image~~:IPLab1Tuberculosis7.jpg~~\|frameless]]~~
	\| This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
	\|-
	~~\| [[Image~~:IPLab1Tuberculosis8.jpg~~\|frameless]]~~
	\| This is a high-power photomicrograph of the Langhans-type multinucleated giant cell which is characteristic of tuberculous granulomas (arrow). Note the horseshoe shape of the nuclei in this giant cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining cells in the peripheral portions of this granuloma to the left of which are lymphocytes.
	\|}

	== Study Questions ==		== Study Questions ==

← Older revision		Revision as of 17:09, 27 June 2019
Line 9:		Line 9:
	File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.		File:IPLab1Tuberculosis2.jpg\|This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.
	File:IPLab1Tuberculosis3.jpg\|This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.		File:IPLab1Tuberculosis3.jpg\|This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.
	File:~~IPLab1Tuberculosis4~~.jpg\|This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the ~~left~~ and the remaining edges are cut edges of the tissue block.		File:IPLab1Tuberculosis4b.jpg\|This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the right and the remaining edges are cut edges of the tissue block.
	File:~~IPLab1Tuberculosis5~~.jpg\|This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.		File:IPLab1Tuberculosis5b.jpg\|This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.
	File:~~IPLab1Tuberculosis6~~.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and ~~occasional~~ multinucleated giant ~~cells~~ around the periphery.		File:IPLab1Tuberculosis6b.jpg\|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (*) and a rim of lymphocytes, macrophages, and a multinucleated giant cell (arrow) around the periphery.
	File:~~IPLab1Tuberculosis7~~.jpg\|This is a higher-power view of ~~the~~ granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant ~~cells near the center~~ (2), and inflammatory cells around the periphery.		File:IPLab1Tuberculosis7b.jpg\|This is a higher-power view of a granuloma with the amorphous eosinophilic material representing caseation necrosis (*), a giant cell (arrow), and inflammatory cells around the periphery.
	File:IPLab1Tuberculosis8b.jpg\|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.
	</gallery>		</gallery>